Study findings have been inconsistent in confirming advantages for mobile-bearing compared with fixed-bearing prostheses for total knee arthroplasty. Therefore, we did meta-analysis of trials comparing outcomes from using the 2 different designs. Of 5670 citations identified for screening, 10 trials reporting 620 participants (906 knees) at final follow-up were eligible for data extraction and meta-analysis. The meta-analysis did not find a significant difference in the American Knee Society Knee Scores, Knee Society Functional and Pain Scores, range of motion, occurrence of radiolucent lines, prosthesis-related complications, and participant preference. The results suggest that the mobile-bearing prosthesis does not offer clinical or radiologic advantage over the fixed-bearing prosthesis.