Coexistence of hepatocellular carcinoma (HCC) and c-Kit negative gastrointestinal stromal tumor (GIST): a case report

South Med J. 2008 Sep;101(9):948-51. doi: 10.1097/SMJ.0b013e31817f027b.

Abstract

A past history of sporadic solid cancers is disclosed in 10% of gastrointestinal stromal tumor (GIST) patients. Simultaneous occurrence with other malignancies is encountered in 14 to 16%, but the synchronous occurrence of GIST and hepatocellular carcinoma (HCC) has been reported only once in the English literature. An 81-year-old male patient is presented with a preoperatively known HCC, in whom a synchronous small nodular omental GIST adjacent to the lesser curvature of the stomach was incidentally discovered. When a GIST is encountered, a thorough intraoperative investigation of the abdominal cavity currently remains the only reliable method for detection of a possible coexisting malignancy.

Publication types

  • Case Reports

MeSH terms

  • Aged, 80 and over
  • Carcinoma, Hepatocellular / complications*
  • Carcinoma, Hepatocellular / diagnosis
  • Carcinoma, Hepatocellular / pathology
  • Carcinoma, Hepatocellular / surgery
  • Catheter Ablation
  • Diagnosis, Differential
  • Gastrointestinal Stromal Tumors / complications*
  • Gastrointestinal Stromal Tumors / diagnosis
  • Gastrointestinal Stromal Tumors / pathology
  • Gastrointestinal Stromal Tumors / surgery
  • Humans
  • Liver Neoplasms / complications*
  • Liver Neoplasms / diagnosis
  • Liver Neoplasms / pathology
  • Liver Neoplasms / surgery
  • Male
  • Omentum / pathology
  • Peritoneal Neoplasms / complications*
  • Peritoneal Neoplasms / diagnosis
  • Peritoneal Neoplasms / pathology
  • Peritoneal Neoplasms / surgery
  • Proto-Oncogene Proteins c-kit / analysis

Substances

  • Proto-Oncogene Proteins c-kit