Abstract
An efficient access to 2-isobetulin, 2-isobetulinic acid, 2-isooleanolic acid, and 2-isoursolic acid has been developed. The key step is a novel one-pot conversion of 2,3-dihydroxy triterpenes to 3-deoxy-2-oxo triterpenes. This method provides a new access to 3-deoxy-2-substituted pentacyclic triterpenes as potential therapeutic agents against metabolic diseases, tumors, and HIV infection.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Betulinic Acid
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Molecular Conformation
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Oleanolic Acid / analogs & derivatives*
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Oleanolic Acid / chemical synthesis*
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Oleanolic Acid / chemistry
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Pentacyclic Triterpenes
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Stereoisomerism
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Triterpenes / chemical synthesis*
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Triterpenes / chemistry*
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Ursolic Acid
Substances
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Pentacyclic Triterpenes
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Triterpenes
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Oleanolic Acid
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Betulinic Acid