Deuterium-labelled p-tyramine challenge test and phenolsulfotransferase activity in depressed patients--failure to replicate decreased p-tyramine conjugation in depression

B A Davis; A A Boulton; P H Yu; D A Durden; R C Bowen; D L Keegan; S Blackshaw; C D'Arcy; A J Remillard; N Dayal

doi:10.1016/0278-5846(91)90087-h

Deuterium-labelled p-tyramine challenge test and phenolsulfotransferase activity in depressed patients--failure to replicate decreased p-tyramine conjugation in depression

Prog Neuropsychopharmacol Biol Psychiatry. 1991;15(2):241-7. doi: 10.1016/0278-5846(91)90087-h.

Authors

B A Davis¹, A A Boulton, P H Yu, D A Durden, R C Bowen, D L Keegan, S Blackshaw, C D'Arcy, A J Remillard, N Dayal, et al.

Affiliation

¹ Neuropsychiatric Research Unit, University of Saskatchewan, Saskatoon.

PMID: 1871324
DOI: 10.1016/0278-5846(91)90087-h

Abstract

1. Depressed and normal subjects were challenged with deuterium-labelled p-tyramine and urine was collected for 3 h. 2. Urinary excretion of conjugated p-tyramine was not significantly different between normal, melancholic and non-melancholic depressed subjects. 3. Platelet phenolsulfotransferase activity to p-tyramine (p less than 0.05) and to phenol (p less than 0.005) were significantly lower in the depressed patients.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amitriptyline / pharmacology
Arylsulfotransferase / metabolism*
Chromatography, Thin Layer
Depressive Disorder / diagnosis
Depressive Disorder / enzymology*
Depressive Disorder / psychology
Double-Blind Method
Female
Fluoxetine / pharmacology
Humans
Male
Psychiatric Status Rating Scales
Random Allocation
Tyramine* / metabolism

Substances

Fluoxetine
Amitriptyline
Arylsulfotransferase
Tyramine