With the aim of optimization of therapy of hepatic cirrhosis with manifestations of system encephalopathy 45 patients were examined. The patients were divided into 2 groups: control group (20 patients who received traditional therapy) and observing group (25 patients who in addition to traditional therapy received cryoapheresis). Clinical symptoms, results of neuropsychological and paraclinical examination, and indices of dynamic hepatobiliscintigraphy against the background of various methods of therapy were studied. It was established that with the use of pathogenetic therapy of hepatic encephalopathy--cryoapheresis--processes of hepatic encephalopathy progressing significantly decelerated, which made possible to approach to the choice of therapy individually, and, thereby, to optimize treatment.