HIV-1 infection: going nuclear with TNPO3/Transportin-SR2 and integrase

Jeremy Luban

doi:10.1016/j.cub.2008.07.037

HIV-1 infection: going nuclear with TNPO3/Transportin-SR2 and integrase

Curr Biol. 2008 Aug 26;18(16):R710-3. doi: 10.1016/j.cub.2008.07.037.

Author

Jeremy Luban¹

Affiliation

¹ Department of Microbiology and Molecular Medicine, University of Geneva, CH-1211 Geneva 4, Switzerland. [email protected]

PMID: 18727908
DOI: 10.1016/j.cub.2008.07.037

Abstract

Factors necessary for HIV-1 nuclear import have been sought for many years. Recent reports suggest that TNPO3/Transportin-SR2 binds to HIV-1 integrase and is required for HIV-1 infection of interphase cells.

MeSH terms

Cell Nucleus / metabolism
Cell Nucleus / virology*
HIV Integrase / metabolism*
HIV-1 / metabolism*
HIV-1 / physiology
Virus Replication*
beta Karyopherins / metabolism*

Substances

beta Karyopherins
transportin SR2
HIV Integrase
p31 integrase protein, Human immunodeficiency virus 1