Antiulcerogenic and anti-inflammatory effects of emodin, isolated from Rhamnus triquerta wall

Indian J Exp Biol. 1991 Mar;29(3):230-2.

Abstract

Emodin, an anthraquinone derivative, isolated from the whole plant of R. triquerta, in 15 mg/kg dose (ip) exhibited anti-inflammatory activity against carrageenin-induced pedal inflammation in rats. In the same dosage it also showed antiulcer activity against 4 hr pylorus-ligated, aspirin and immobilization stress-induced gastric ulcers in rats. It decreased acid and pepsin output and augmented mucus secretion in terms of total carbohydrate: protein ratio in the gastric juice of aspirin treated pylorus-ligated rats, indicating that the antiulcerogenic effect of emodin may be due to its effect on gastric secretion.

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal
  • Anti-Ulcer Agents
  • Emodin / isolation & purification
  • Emodin / pharmacology*
  • Female
  • Gastric Juice / drug effects
  • Gastric Juice / metabolism
  • Inflammation / prevention & control
  • Male
  • Rats
  • Ulcer / prevention & control

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Anti-Ulcer Agents
  • Emodin