1,25-Dihydroxycholecalciferol inhibits the cochemotactic activity of Gc (vitamin D binding protein)

M Petrini; A Azzarà; G Carulli; B Grassi; F Ambrogi; R M Galbraith

doi:10.1007/BF03349090

1,25-Dihydroxycholecalciferol inhibits the cochemotactic activity of Gc (vitamin D binding protein)

J Endocrinol Invest. 1991 May;14(5):405-8. doi: 10.1007/BF03349090.

Authors

M Petrini¹, A Azzarà, G Carulli, B Grassi, F Ambrogi, R M Galbraith

Affiliation

¹ Servizio di Ematologia, Università di Pisa, Italy.

PMID: 1875017
DOI: 10.1007/BF03349090

Abstract

The identification of Gc (vitamin D binding protein) with the anionic polypeptide cochemotaxin has recently been reported. In this paper we investigate its dose dependent cochemotactic activity and report the inhibition of Gc enhanced chemotaxis by vitamin D3. These results further support the role of immunomodulating hormone played by vitamin D.

MeSH terms

Adjuvants, Immunologic / pharmacology
Calcitriol / pharmacology*
Calcitriol / physiology
Cell Movement / drug effects
Cell Movement / physiology
Chemotaxis / drug effects*
Chemotaxis / physiology
Dose-Response Relationship, Drug
Humans
Leukocytes / drug effects
Leukocytes / physiology
Vitamin D-Binding Protein / physiology*

Substances

Adjuvants, Immunologic
Vitamin D-Binding Protein
Calcitriol