Abstract
Regulatory T cells are in the focus of research on autoimmunity. However, recent findings suggest that pro-inflammatory T(H)1 cells themselves exert important immunoregulatory functions. This physiological self-limiting mechanism holds great promise for therapeutic interventions.
MeSH terms
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Adaptor Proteins, Signal Transducing
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Autoimmune Diseases / immunology*
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Calcium-Binding Proteins
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Cytokines / blood
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Humans
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Intercellular Signaling Peptides and Proteins / physiology
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Interleukin-10 / blood
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Interleukin-12 / blood
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Interleukin-2 / blood
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Lymphocyte Activation / immunology*
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Receptors, Notch / physiology
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Signal Transduction / physiology
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T-Lymphocytes, Regulatory / immunology*
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Th1 Cells / immunology*
Substances
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Adaptor Proteins, Signal Transducing
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Calcium-Binding Proteins
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Cytokines
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DLL4 protein, human
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Intercellular Signaling Peptides and Proteins
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Interleukin-2
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Receptors, Notch
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Interleukin-10
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Interleukin-12