Abstract
A novel series of bacterial topoisomerase (3-aminoquinazolinediones) inhibitors are described. The side-chain SAR against Gram-positive and Gram-negative organisms as well as DNA gyrase activity is reported.
MeSH terms
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Anti-Bacterial Agents* / chemical synthesis
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Anti-Bacterial Agents* / chemistry
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Anti-Bacterial Agents* / pharmacology
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Combinatorial Chemistry Techniques
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Fluoroquinolones / chemical synthesis
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Fluoroquinolones / chemistry
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Fluoroquinolones / pharmacology
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Gram-Negative Bacteria / drug effects*
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Gram-Negative Bacteria / enzymology*
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Gram-Positive Bacteria / drug effects*
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Gram-Positive Bacteria / enzymology*
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Microbial Sensitivity Tests
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Molecular Structure
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Quinazolinones* / chemical synthesis
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Quinazolinones* / chemistry
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Quinazolinones* / pharmacology
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Structure-Activity Relationship
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Topoisomerase II Inhibitors*
Substances
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Anti-Bacterial Agents
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Fluoroquinolones
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Quinazolinones
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Topoisomerase II Inhibitors