Clioquinol inhibits the proteasome and displays preclinical activity in leukemia and myeloma

Leukemia. 2009 Mar;23(3):585-90. doi: 10.1038/leu.2008.232. Epub 2008 Aug 28.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / adverse effects
  • Antineoplastic Agents / pharmacology*
  • Antineoplastic Agents / therapeutic use
  • Archaeal Proteins / antagonists & inhibitors
  • Asian People
  • Cell Line, Tumor / drug effects
  • Cell Line, Tumor / enzymology
  • Clioquinol / adverse effects
  • Clioquinol / pharmacology*
  • Clioquinol / therapeutic use
  • Copper / antagonists & inhibitors
  • Copper / pharmacology
  • Drug Screening Assays, Antitumor
  • Endopeptidases
  • Humans
  • Japan
  • K562 Cells / drug effects
  • K562 Cells / enzymology
  • K562 Cells / transplantation
  • Leukemia, Experimental / drug therapy*
  • Leukemia, Experimental / enzymology
  • Leukemia, Myeloid, Acute / enzymology*
  • Leukemia, Myeloid, Acute / pathology
  • Mice
  • Mice, Inbred NOD
  • Mice, SCID
  • Multiple Myeloma / enzymology*
  • Multiple Myeloma / pathology
  • Neoplasm Proteins / antagonists & inhibitors*
  • Optic Nerve Diseases / chemically induced
  • Optic Nerve Diseases / ethnology
  • Protease Inhibitors / adverse effects
  • Protease Inhibitors / pharmacology*
  • Protease Inhibitors / therapeutic use
  • Proteasome Endopeptidase Complex
  • Proteasome Inhibitors*
  • Spinal Cord Diseases / chemically induced
  • Spinal Cord Diseases / ethnology
  • U937 Cells / drug effects
  • U937 Cells / enzymology
  • U937 Cells / transplantation

Substances

  • Antineoplastic Agents
  • Archaeal Proteins
  • Neoplasm Proteins
  • Protease Inhibitors
  • Proteasome Inhibitors
  • Copper
  • Clioquinol
  • Endopeptidases
  • Proteasome Endopeptidase Complex
  • ATP dependent 26S protease
  • proteasome, Thermoplasma