Abstract
Fluoroquinolone resistance in Streptococcus pyogenes has been reported only anecdotally, but a recent Belgian surveillance study found a rate of nonsusceptibility of 5.4%. From an analysis of these isolates, we show that interspecies horizontal gene transfer within the parC quinolone resistance-determining region is a frequent phenomenon that might contribute to fluoroquinolone resistance.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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DNA Topoisomerase IV / genetics
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Drug Resistance, Bacterial / genetics*
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Fluoroquinolones / pharmacology*
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Gene Transfer, Horizontal
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Genes, Bacterial
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Humans
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Phylogeny
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Recombination, Genetic
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Species Specificity
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Streptococcal Infections / drug therapy
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Streptococcal Infections / microbiology
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Streptococcus pyogenes / drug effects*
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Streptococcus pyogenes / genetics*
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Streptococcus pyogenes / isolation & purification
Substances
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Anti-Bacterial Agents
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Fluoroquinolones
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DNA Topoisomerase IV