Abstract
We report a patient with Enterococcus faecalis native-valve endocarditis who relapsed after 4 weeks of treatment with ampicillin plus gentamicin. The relapse was cured with ampicillin plus ceftriaxone, which was introduced after gentamicin-induced acute renal failure. This double beta-lactam combination showed a bactericidal effect in time-killing curve studies.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Ampicillin / administration & dosage*
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Ampicillin / therapeutic use
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Anti-Bacterial Agents / administration & dosage
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Anti-Bacterial Agents / therapeutic use
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Ceftriaxone / administration & dosage*
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Ceftriaxone / therapeutic use
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Dose-Response Relationship, Drug
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Drug Therapy, Combination
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Endocarditis, Bacterial / drug therapy*
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Endocarditis, Bacterial / microbiology
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Enterococcus faecalis* / drug effects
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Female
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Gram-Positive Bacterial Infections / drug therapy*
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Gram-Positive Bacterial Infections / microbiology
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Humans
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Microbial Sensitivity Tests
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beta-Lactam Resistance
Substances
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Anti-Bacterial Agents
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Ceftriaxone
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Ampicillin