Abstract
Diffuse large B-cell lymphoma represent 40% of all lymphoma. The development of dose-dense chemotherapeutic regimens and the application of the monoclonal CD20 antibody rituximab improve the prognosis significantly. Evaluation of clinical risk factors (age, stage, LDH, ECOG performance status, number of extranodal involvement) at initial diagnosis are the most important approaches for risk stratification that allows risk adapted modifications of the standard R-CHOP regimen.
Publication types
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Case Reports
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English Abstract
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Review
MeSH terms
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Aged
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Antibodies, Monoclonal / therapeutic use*
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Antibodies, Monoclonal, Murine-Derived
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Antineoplastic Agents / therapeutic use*
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
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Cyclophosphamide / therapeutic use
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Diagnosis, Differential
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Doxorubicin / therapeutic use
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Female
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Humans
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Immunologic Factors / therapeutic use*
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Lymphoma, Large B-Cell, Diffuse / diagnosis
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Lymphoma, Large B-Cell, Diffuse / drug therapy*
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Lymphoma, Large B-Cell, Diffuse / epidemiology
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Lymphoma, Large B-Cell, Diffuse / radiotherapy
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Prednisone / therapeutic use
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Prognosis
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Radiotherapy, Adjuvant
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Risk Factors
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Rituximab
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Vincristine / therapeutic use
Substances
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Antibodies, Monoclonal
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Antibodies, Monoclonal, Murine-Derived
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Antineoplastic Agents
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Immunologic Factors
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Rituximab
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Vincristine
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Doxorubicin
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Cyclophosphamide
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Prednisone