Design and synthesis of novel oxindoles as potential non-nucleosidic reverse transcriptase inhibitors against HIV

Garima Kumari; Ramendra K Singh

doi:10.1093/nass/nrn134

Design and synthesis of novel oxindoles as potential non-nucleosidic reverse transcriptase inhibitors against HIV

Nucleic Acids Symp Ser (Oxf). 2008:(52):265-6. doi: 10.1093/nass/nrn134.

Authors

Garima Kumari¹, Ramendra K Singh

Affiliation

¹ Nucleic Acids Research Laboratory, Department of Chemistry, University of Allahabad, Allahabad-211002, India.

PMID: 18776355
DOI: 10.1093/nass/nrn134

Abstract

We describe here the synthesis of novel oxindoles by cycloproponation of its diazo derivatives. The synthesis involves the use of allyl methyl sulfide and allyl alcohol as olefins and rhodium acetate as catalyst. These oxindoles have been designed to act as non-nucleosidic reverse transcriptase inhibitors (NNRTIs) against HIV.

MeSH terms

Anti-HIV Agents / chemical synthesis*
Anti-HIV Agents / chemistry
Drug Design
Indoles / chemical synthesis*
Indoles / chemistry
Oxindoles
Reverse Transcriptase Inhibitors / chemical synthesis*
Reverse Transcriptase Inhibitors / chemistry

Substances

Anti-HIV Agents
Indoles
Oxindoles
Reverse Transcriptase Inhibitors
2-oxindole