Abstract
Dinucleotide cap analogs containing tetraphosphate bridge modified by replacing one of the bridging oxygen atoms with methylene group were synthesized. The analogs have been examined for their stability towards enzymatic hydrolysis by human DcpS and binding affinity for eIF4E. Their inhibitory properties in rabbit reticulocyte lysate (RRL) translational system were studied.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Diphosphonates / chemistry*
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Endoribonucleases / metabolism
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Eukaryotic Initiation Factor-4E / metabolism
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Humans
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Protein Biosynthesis
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RNA Cap Analogs / chemical synthesis
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RNA Cap Analogs / chemistry*
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Rabbits
Substances
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Diphosphonates
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Eukaryotic Initiation Factor-4E
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RNA Cap Analogs
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Endoribonucleases
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DcpS protein, human