Abstract
Transition metal complex catalysed cocyclotrimerization of 6-alkynylpurines 1 with various diynes 2 and 6-(diynyl)purines 4 with nitriles 5 enabled to synthesize series of substituted 6-arylpurines 3 and 6-heteroarylpurines 6 in good yields. The obtained 6-aryl- and 6-heteroarylpurines were tested for cytostatic activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cell Line
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Cell Line, Tumor
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Cobalt / chemistry
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Cytostatic Agents / chemical synthesis
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Cytostatic Agents / chemistry
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Cytostatic Agents / pharmacology
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Diynes / chemistry
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Humans
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Mice
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Nitriles / chemistry
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Purines / chemical synthesis*
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Purines / chemistry
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Purines / pharmacology
Substances
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Cytostatic Agents
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Diynes
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Nitriles
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Purines
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Cobalt