Abstract
A series of N10-substituted-2-methyl acridone derivatives are synthesized and are examined for its ability to reverse P-glycoprotein (P-gp) mediated multidrug resistance (MDR) in breast cancer cell lines MCF-7 and MCF-7/Adr. The structural requirement of in-vitro anti-cancer and reversal of drug resistance are studied. The results showed that compound 16 with four carbon spacer exhibited promising in-vitro anti-cancer and reversal of drug resistance in comparison to the other analogues.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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ATP Binding Cassette Transporter, Subfamily B, Member 1 / metabolism
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Acridones / chemical synthesis
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Acridones / pharmacology*
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / pharmacology*
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Breast Neoplasms / metabolism
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Breast Neoplasms / pathology
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Cell Line, Tumor / drug effects
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Cell Line, Tumor / pathology
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Drug Resistance, Neoplasm*
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Humans
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Models, Chemical
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Multidrug Resistance-Associated Proteins / antagonists & inhibitors*
Substances
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ATP Binding Cassette Transporter, Subfamily B, Member 1
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Acridones
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Antineoplastic Agents
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Multidrug Resistance-Associated Proteins