[Expression of MMP-2, MMP-9 and collagen type IV and their relationship in colorectal carcinomas]

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2008 Sep;24(9):908-9.
[Article in Chinese]

Abstract

Aim: To investigate the expression of MMP-2, MMP-9 and collagen type IV and their relationship in colorectal carcinomas.

Methods: The expressions of collagen type IV, MMP-2 and MMP-9 was in normal and colorectal cancer tissues of 30 patients whose clinical stages were Dukes'B and C was detected with immunohistochennical staining. And the relationship among collagen type IV, MMP-2 and MMP-9 was analysed.

Results: The expression of collagen type IV was significantly decreased in colorectal cancer tissues. The expression of MMP-2 and MMP-9 was not detected in normal colorectal tissues but it was significantly increased in colorectal cancer tissues. There was a negative correlation between the expression of collagen type IV and MMP-9.

Conclusion: The expression of collagen type IV in colorectal cancer tissues is lower than that in normal tissues. MMP-9 may play an important role in the degradation of collagen type IV in colorectal cancer.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Collagen Type IV / genetics*
  • Collagen Type IV / metabolism
  • Colorectal Neoplasms / enzymology*
  • Colorectal Neoplasms / genetics
  • Colorectal Neoplasms / pathology
  • Female
  • Gene Expression Regulation, Neoplastic*
  • Humans
  • Male
  • Matrix Metalloproteinase 2 / genetics*
  • Matrix Metalloproteinase 2 / metabolism
  • Matrix Metalloproteinase 9 / genetics*
  • Matrix Metalloproteinase 9 / metabolism
  • Middle Aged
  • Neoplasm Staging

Substances

  • Collagen Type IV
  • Matrix Metalloproteinase 2
  • Matrix Metalloproteinase 9