Abstract
Variants in the Omi/HtrA2 gene have been nominated as a cause of Parkinson's disease. This sequencing study of Omi/HtrA2 in 95 probands with apparent autosomal dominant inheritance of Parkinson's disease did not identify any pathogenic mutations. In addition, there was no association between common variations in the Omi/HtrA2 gene and susceptibility to Parkinson's disease in any of our four patient-control series (n=2373). Taken together our results do not support a role for Omi/HtrA2 variants in the pathogenesis of Parkinson's disease.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Chi-Square Distribution
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Female
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Gene Frequency
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Genetic Predisposition to Disease*
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Genetic Testing
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Genetic Variation / genetics*
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High-Temperature Requirement A Serine Peptidase 2
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Humans
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Logistic Models
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Male
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Middle Aged
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Mitochondrial Proteins / genetics*
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Molecular Sequence Data
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Parkinson Disease / genetics*
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Serine Endopeptidases / genetics*
Substances
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Mitochondrial Proteins
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Serine Endopeptidases
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HTRA2 protein, human
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High-Temperature Requirement A Serine Peptidase 2