Rare and unusual histological variants of prostatic carcinoma: clinical significance

BJU Int. 2008 Nov;102(10):1369-74. doi: 10.1111/j.1464-410X.2008.08074.x. Epub 2008 Sep 12.

Abstract

We review the clinicopathological features of the following unusual histological variants of prostatic carcinoma: small cell carcinoma, ductal adenocarcinoma, sarcomatoid (carcinosarcoma), basal cell, squamous cell and adenosquamous, and urothelial carcinoma. These variants are rare and account for 5-10% of carcinomas that originate in the prostate. Some develop from acinar adenocarcinoma after hormonal or radiation therapy. They are usually aggressive tumours that often present with secondary deposits. The outcome is generally poor. Only basal cell carcinoma is seen as a low-grade carcinoma.

Publication types

  • Review

MeSH terms

  • Adenocarcinoma / pathology
  • Adult
  • Aged
  • Aged, 80 and over
  • Carcinoma, Acinar Cell / pathology
  • Carcinoma, Small Cell / pathology
  • Carcinoma, Squamous Cell / pathology
  • Carcinoma, Transitional Cell / pathology
  • Carcinosarcoma / pathology
  • Humans
  • Male
  • Middle Aged
  • Prognosis
  • Prostatic Neoplasms / pathology*