Synthesis and nematocidal activities of jietacin A and its analogs

J Antibiot (Tokyo). 1991 Jul;44(7):774-84. doi: 10.7164/antibiotics.44.774.

Abstract

Simple, efficient syntheses of jietacin A, a nematocidal antibiotic, and its analogs have been developed in order to study structure-activity relationships. A series of alpha,beta-unsaturated azoxy compounds was prepared from phenylselenomethyl azoxy compounds as key intermediates and its nematocidal activity was determined.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Antinematodal Agents / chemical synthesis*
  • Antinematodal Agents / chemistry
  • Antinematodal Agents / pharmacology
  • Azo Compounds / chemical synthesis*
  • Azo Compounds / chemistry
  • Azo Compounds / pharmacology
  • Molecular Structure
  • Nematoda / drug effects
  • Structure-Activity Relationship

Substances

  • Antinematodal Agents
  • Azo Compounds
  • jietacin A