Abstract
A series of fused tetracycles with a benzene or cyclohexadiene core (2a-h) is satisfactorily prepared by intramolecular [2 + 2 + 2] cycloadditions of triynic and enediynic macrocycles (1a-h) under RhCl(PPh3)3 catalysis; the enantioselective cycloaddition of macrocycles 1b and 1e and gives chiral tetracycles with moderate enantiomeric excess.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkynes / chemical synthesis*
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Alkynes / chemistry
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Benzene / chemistry*
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Catalysis
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Cyclization
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Cyclohexenes / chemistry*
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Heterocyclic Compounds, 4 or More Rings / chemical synthesis*
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Heterocyclic Compounds, 4 or More Rings / chemistry
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Macrocyclic Compounds / chemical synthesis
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Macrocyclic Compounds / chemistry*
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Molecular Structure
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Organometallic Compounds / chemistry
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Rhodium / chemistry
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Stereoisomerism
Substances
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Alkynes
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Cyclohexenes
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Heterocyclic Compounds, 4 or More Rings
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Macrocyclic Compounds
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Organometallic Compounds
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Rhodium
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Benzene