Selective synthesis of double temperature-sensitive polymer-peptide conjugates

Chem Commun (Camb). 2008 Oct 7:(37):4433-5. doi: 10.1039/b806782a. Epub 2008 Jul 16.

Abstract

A novel synthetic route has been developed to couple selectively a modified octa-peptide, that is able to gel at low temperature, to the prototypical thermoresponsive polymer poly(N-isopropylacrylamide) to give a bioconjugate that exhibits double thermoresponsiveness.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acrylamides / chemistry*
  • Acrylic Resins
  • Calorimetry, Differential Scanning
  • Peptides / chemistry*
  • Polymers / chemistry*
  • Temperature*

Substances

  • Acrylamides
  • Acrylic Resins
  • Peptides
  • Polymers
  • poly-N-isopropylacrylamide