Studies on the synthesis of durhamycin A: stereoselective synthesis of a model aglycone

Org Lett. 2008 Oct 16;10(20):4613-6. doi: 10.1021/ol8018727. Epub 2008 Sep 23.

Abstract

A stereoselective synthesis of the model aglycone corresponding to the anti-HIV aureolic acids durhamycins A (1) and B (2) is described.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Aldehydes / chemistry
  • Alkadienes / chemistry
  • Fatty Alcohols / chemistry
  • Molecular Structure
  • Plicamycin / analogs & derivatives*
  • Plicamycin / chemical synthesis
  • Plicamycin / chemistry
  • Stereoisomerism
  • Temperature

Substances

  • Aldehydes
  • Alkadienes
  • Fatty Alcohols
  • durhamycin A
  • propadiene
  • acyloin
  • Plicamycin