Synthesis, characterization, and DNA-binding properties of Ln(III) complexes containing gatifloxacin

J Biomol Struct Dyn. 2008 Dec;26(3):293-300. doi: 10.1080/07391102.2008.10507244.

Abstract

Four novel water-soluble complexes of Ln(III) with gatifloxacin (HGA), [La(HGA)3Cl3] x 2H2O, [Nd(HGA)3Cl3] x 2H2O, [Eu(HGA)3Cl3] x 2H2O, [Tb(HGA)3Cl3] x 2H2O, have been synthesized and characterized by elemental analyses, molar conductivities, IR spectra, fluorescence spectra, and thermogravimetry/differential thermal analysis (TG-DTA). In addition, the DNA-binding properties of the ligand and its complexes have been investigated by absorption, fluorescence spectra, and viscosity measurements. The experimental results indicated that the complexes and ligand bind to DNA via groove binding mode.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Infective Agents* / chemistry
  • Anti-Infective Agents* / metabolism
  • DNA* / chemistry
  • DNA* / metabolism
  • Fluoroquinolones* / chemistry
  • Fluoroquinolones* / metabolism
  • Gatifloxacin
  • Lanthanum / chemistry*
  • Molecular Structure
  • Spectrometry, Fluorescence
  • Viscosity

Substances

  • Anti-Infective Agents
  • Fluoroquinolones
  • Lanthanum
  • DNA
  • Gatifloxacin