Is fluorouracil-induced severe toxicity in DPYD*2A individuals related to sex or to treatment regimen?

J Clin Oncol. 2008 Oct 20;26(30):4997-8; author reply 4998-9. doi: 10.1200/JCO.2008.18.8565. Epub 2008 Sep 22.
No abstract available

Publication types

  • Comment
  • Letter

MeSH terms

  • Antimetabolites, Antineoplastic / adverse effects*
  • Dihydrouracil Dehydrogenase (NADP) / genetics*
  • Drug-Related Side Effects and Adverse Reactions / genetics*
  • Female
  • Fluorouracil / adverse effects*
  • Fluorouracil / pharmacokinetics
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Male
  • Polymorphism, Genetic
  • Sex Factors

Substances

  • Antimetabolites, Antineoplastic
  • Dihydrouracil Dehydrogenase (NADP)
  • Fluorouracil