Abstract
Hypophosphatemic osteomalacia first presenting in adulthood is a rare disease. It is characterized by decreased serum phosphate, renal phosphate wasting, elevated alkaline phosphatase, and osteomalacia. The authors present a case with typical constellation of an oncogenic (tumor-induced) osteomalacia, the possible differential diagnosis, diagnostic evaluation, and complete healing after tumor resection. The new concepts of hereditary and acquired hypophosphatemic osteomalacia are discussed helping us understand this rare disease.
Publication types
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Case Reports
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Comparative Study
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English Abstract
MeSH terms
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Adult
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Biopsy
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Bone Neoplasms / complications*
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Bone Neoplasms / diagnosis
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Bone Neoplasms / pathology
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Bone Neoplasms / surgery
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Diagnosis, Differential
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Fibroblast Growth Factors / blood
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Follow-Up Studies
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Giant Cell Tumor of Bone / complications*
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Giant Cell Tumor of Bone / diagnosis
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Giant Cell Tumor of Bone / pathology
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Giant Cell Tumor of Bone / surgery
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Humans
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Hypophosphatemia / diagnosis
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Hypophosphatemia / etiology*
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Male
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Metatarsus
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Osteolysis / etiology
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Osteomalacia / etiology*
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Paraneoplastic Syndromes / diagnosis*
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Parathyroid Hormone / blood
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Radiography, Abdominal
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Ribs / pathology
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Time Factors
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Tomography, X-Ray Computed
Substances
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Parathyroid Hormone
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Fibroblast Growth Factors