Abstract
The association of a monoclonal gammopathy (MG) with a B cell non-Hodgkin's lymphoma (NHL) is a well-known phenomenon. It has been recognized in many subtypes of primary gastrointestinal lymphoma but its association with primary colonic mantle cell lymphoma has never been yet described. We report a 65-year-old man who presented with an exudative ascites and constipation. Serum electrophoresis showed a monoclonal peak in the gamma region of 45g/L and immunoelectrophoresis confirmed the presence of monoclonal gammopathy of IgM kappa type. Bone marrow aspirate was normal. Radiologic and endoscopic investigations evidenced a primary colonic mantle cell lymphoma. Although the association of an MG with an NHL and, in particular, to a primitive digestive location appears a rare phenomenon, endoscopic investigations in patients with MG appears legitimate in the presence of any digestive sign.
MeSH terms
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Aged
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Antibodies, Monoclonal / administration & dosage
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Antibodies, Monoclonal / therapeutic use
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Antibodies, Monoclonal, Murine-Derived
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Antineoplastic Agents / administration & dosage
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Antineoplastic Agents / therapeutic use
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Colon / pathology
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Colonic Neoplasms / complications*
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Colonic Neoplasms / diagnostic imaging
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Colonic Neoplasms / drug therapy
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Colonic Neoplasms / pathology
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Cyclophosphamide / therapeutic use
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Doxorubicin / therapeutic use
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Follow-Up Studies
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Humans
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Immunoelectrophoresis
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Lymphoma, Mantle-Cell / complications*
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Lymphoma, Mantle-Cell / diagnostic imaging
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Lymphoma, Mantle-Cell / drug therapy
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Lymphoma, Mantle-Cell / pathology
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Male
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Neoplasm Staging
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Paraproteinemias / complications*
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Paraproteinemias / diagnosis
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Prednisone / therapeutic use
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Radiography, Abdominal
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Rituximab
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Time Factors
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Tomography, X-Ray Computed
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Treatment Outcome
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Vincristine / therapeutic use
Substances
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Antibodies, Monoclonal
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Antibodies, Monoclonal, Murine-Derived
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Antineoplastic Agents
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Rituximab
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Vincristine
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Doxorubicin
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Cyclophosphamide
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Prednisone