Abstract
A concise sequence utilizing a Petasis three component reaction followed by a tandem aza-Cope-Mannich cyclization afforded novel polycyclic heterocycles in good yield; alternative iminium cyclization based on a Pictet-Spengler reaction or aminal formation led to divergent pathways affording skeletal diversity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aza Compounds / chemistry
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Cyclization
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Heterocyclic Compounds / chemical synthesis
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Indicators and Reagents / chemistry*
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Mannich Bases / chemistry
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Polycyclic Compounds / chemical synthesis*
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Polymers / chemistry*
Substances
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Aza Compounds
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Heterocyclic Compounds
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Indicators and Reagents
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Mannich Bases
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Polycyclic Compounds
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Polymers