Abstract
A series of novel 4beta-[(4-substituted)-1,2,3-triazol-1-yl]podophyllotoxin derivatives were synthesized by employing Cu(I)-catalyzed click chemistry and evaluated for their anticancer activity against a panel of seven human cancer cell lines (HT-29, HCT-15, 502713, HOP-62, A-549, MCF-7, and SF-295). The compounds 9b, 9c, 9e, 9f, and 9h showed significant cytotoxic activities especially against HT-29, HCT-15, 502713 cell lines.
MeSH terms
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Cell Line, Tumor
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Cell Survival / drug effects
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Drug Screening Assays, Antitumor
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Humans
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Molecular Structure
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Podophyllotoxin / chemical synthesis*
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Podophyllotoxin / chemistry
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Podophyllotoxin / pharmacology*
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Structure-Activity Relationship
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Triazoles / chemistry*
Substances
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Antineoplastic Agents
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Triazoles
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Podophyllotoxin