Preterm birth or foetal growth impairment and psychiatric hospitalization in adolescence and early adulthood in a Swedish population-based birth cohort

Acta Psychiatr Scand. 2009 Jan;119(1):54-61. doi: 10.1111/j.1600-0447.2008.01267.x. Epub 2008 Sep 19.

Abstract

Objective: Preterm birth and restricted foetal growth are related to symptoms of psychiatric disorder. Our aim was therefore to investigate possible relations between being born preterm and/or small for gestational age (SGA) and later psychiatric hospitalization.

Method: A population-based registry study of psychiatric hospitalization of in total 155,994 boys and 148,281 girls born in Sweden in 1973-1975.

Results: The risk of hospitalization for all mental disorders was increased for preterm SGA boys (OR 2.19, 95% CI 1.49-3.21); at-term SGA boys (OR 1.55, 95% CI 1.34-1.79); at-term SGA girls (OR 1.31, 95% CI 1.15-1.50). At-term SGA boys and girls suffered increased risk of anxiety and adjustment disorders (OR 1.70, 95% CI 1.18-2.45 and OR 1.49, 95% CI 1.14-1.94). Preterm SGA boys were at risk of personality disorders (OR 3.30, 95% CI 1.16-9.41) and psychotic disorders (OR 4.36, 95% CI 1.85-10.30).

Conclusion: The results show a relationship between being born SGA and later psychiatric hospitalization, where preterm birth and male gender seem to increase the risk.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adjustment Disorders / epidemiology
  • Adolescent
  • Anxiety Disorders / epidemiology
  • Cohort Studies
  • Female
  • Fetal Growth Retardation / epidemiology*
  • Hospitals, Psychiatric*
  • Humans
  • Infant, Newborn
  • Infant, Premature, Diseases / epidemiology*
  • Infant, Small for Gestational Age*
  • Male
  • Mental Disorders / epidemiology*
  • Mood Disorders / epidemiology
  • Patient Admission / statistics & numerical data*
  • Personality Disorders / epidemiology
  • Pregnancy
  • Psychotic Disorders / epidemiology
  • Registries / statistics & numerical data
  • Risk Factors
  • Sex Factors
  • Statistics as Topic
  • Sweden
  • Young Adult