Objective: To summarize and review the heterogeneity of bone marrow derived stem cells (BMDSCs) and its formation mechanism and significance, and to analyze the possible roles and mechanisms in intestinal epithelial reconstruction.
Methods: The related literature about BMDSCs heterogeneity and its role in intestinal epithelial repair was reviewed and analyzed.
Results: The heterogeneity of BMDSCs provided better explanations for its multi-potency. The probable mechanisms of BMDSCs to repair intestinal epithelium included direct implantation into intestinal epithelium, fusion between BMDSCs and intestinal stem cells, and promotion of injury microcirculation reconstruction.
Conclusion: BMDSCs have a bright future in gastrointestinal injury caused by inflammatory bowl disease and regeneration.