Abstract
The metabolites of a marine streptomyces sp. actinomycete (No. 195-02) were studied and eight compounds were isolated from the fermentation liquid, structures were elucidated by spectroscopy methods as p-hydroxy-benzonitrile (1), 2-methyl-furan-3-carboxylic acid(2), furan-2-carboxylic acid (3), cyclo(Phe-Phe) (4), cyclo(Leu-Ileu) (5), nicotinic acid (6), 2-(1H-indol-3-yl) acetic acid (7) and bis(2-ethylhexyl) phthalate (8). The compounds 1, 3 and 8 were firstly isolated from Streptomyces sp., compounds 4 -7 were firstly found from marine actinomycetes. Coumpouds 4 and 5 evidently inhibited the growth of cancer cell lines hepG2 and hep2 at the concentration of 50 microg/ml.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / pharmacology
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China
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Chlorobenzoates / chemistry
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Chlorobenzoates / isolation & purification*
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Diethylhexyl Phthalate / chemistry
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Diethylhexyl Phthalate / isolation & purification
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Furans / chemistry
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Furans / isolation & purification*
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Indoleacetic Acids / chemistry
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Indoleacetic Acids / isolation & purification*
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Magnetic Resonance Spectroscopy
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Marine Biology
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Molecular Structure
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Peptides, Cyclic / chemistry
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Peptides, Cyclic / isolation & purification*
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Peptides, Cyclic / pharmacology
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Streptomyces / chemistry*
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Streptomyces / metabolism
Substances
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(6-chloro-2-(4-chlorobenzoyl)-1H-indol-3-yl)acetic acid
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Antineoplastic Agents
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Chlorobenzoates
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Furans
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Indoleacetic Acids
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Peptides, Cyclic
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Diethylhexyl Phthalate
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2-furoic acid