Abstract
Carbapenem-resistant Acinetobacter baumannii (CR-Ab) ranked third, with a frequency of 24.8%, among 202 strains of multidrug-resistant bacteria isolated from clinical samples in the main hospital of New Caledonia in 2004. All CR-Ab isolates were analysed by isoelectric focusing, conjugation, pulsed-field gel electrophoresis and PCR for the presence of carbapenemase genes. Fifty CR-Ab isolates produced carbapenemase OXA-23. The isolates belonged to a single clone presenting several subtypes, suggesting an endemic situation. This study further illustrates the widespread prevalence of carbapenemase OXA-23-producing CR-Ab isolates in the South Pacific.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acinetobacter Infections / epidemiology*
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Acinetobacter Infections / microbiology*
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Acinetobacter baumannii / chemistry
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Acinetobacter baumannii / classification*
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Acinetobacter baumannii / drug effects*
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Acinetobacter baumannii / genetics
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Anti-Bacterial Agents / pharmacology*
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Bacterial Proteins / analysis
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Bacterial Proteins / genetics
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Carbapenems / pharmacology*
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Cluster Analysis
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Conjugation, Genetic
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DNA Fingerprinting
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DNA, Bacterial / genetics
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Drug Resistance, Bacterial*
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Electrophoresis, Gel, Pulsed-Field
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Genotype
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Humans
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Isoelectric Focusing
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Molecular Epidemiology*
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New Caledonia / epidemiology
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Polymerase Chain Reaction
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beta-Lactamases / genetics
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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Carbapenems
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DNA, Bacterial
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beta-Lactamases
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carbapenemase