Abstract
Chronic active Epstein-Barr virus (EBV) infection is a rare chronic mononucleosis syndrome involving clonally proliferating EBV-infected T-/NK-cells. EBV DNA was quantified in nonpleocytotic cerebrospinal fluid (CSF) of 9 patients. Three patients with neurologic and/or neuroimaging abnormalities showed high CSF copy numbers. In 1 patient, CSF copy number exceeded the peripheral blood value. CSF EBV-load may predict the central nervous system involvement of EBVT-/NK-cells.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Cerebrospinal Fluid / virology*
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Child
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Child, Preschool
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Chronic Disease
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Female
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Hematopoietic Stem Cell Transplantation
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Herpesvirus 4, Human / genetics
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Herpesvirus 4, Human / isolation & purification
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Herpesvirus 4, Human / physiology*
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Humans
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Infectious Mononucleosis / cerebrospinal fluid
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Infectious Mononucleosis / virology*
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Killer Cells, Natural
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Magnetic Resonance Imaging
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Male
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Polymerase Chain Reaction
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T-Lymphocytes
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Viral Load