Abstract
The new chlorinated peptides sintokamides A to E (1-5) have been isolated from specimens of the marine sponge Dysidea sp. collected in Indonesia. Their structures were elucidated by a combination of spectroscopic and single-crystal X-ray diffraction analyses. Sintokamide A (1) is an inhibitor of N-terminus transactivation of the androgen receptor in prostate cancer cells.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Animals
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Cell Line, Tumor
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Chlorine Compounds / chemistry*
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Chlorine Compounds / pharmacology*
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Dysidea / chemistry*
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Humans
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Magnetic Resonance Spectroscopy
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Male
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Models, Molecular
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Molecular Structure
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Peptides / chemistry*
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Peptides / pharmacology*
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Prostatic Neoplasms / genetics
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Prostatic Neoplasms / metabolism*
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Receptors, Androgen / genetics
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Receptors, Androgen / metabolism*
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Transcriptional Activation / drug effects
Substances
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Chlorine Compounds
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Peptides
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Receptors, Androgen