Abstract
Knowledge of the distinctive cellular and genetic traits of a cancer aids in diagnosis, prognosis, and potentially treatment. In this issue of Cancer Cell, Kotecha et al. (2008) demonstrate using a sophisticated flow cytometry approach that signal transduction responses to exogenous stimulation can inform diagnosis and pathobiology of myeloproliferative neoplasms.
Publication types
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Comment
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Research Support, Non-U.S. Gov't
MeSH terms
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Biomarkers, Tumor / metabolism*
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Cell Proliferation
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Child
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Disease Progression
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Flow Cytometry*
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Gene Expression Regulation, Neoplastic
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Granulocyte-Macrophage Colony-Stimulating Factor / metabolism
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Humans
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Janus Kinase 2 / metabolism
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Leukemia, Myelomonocytic, Juvenile / genetics
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Leukemia, Myelomonocytic, Juvenile / metabolism*
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Leukemia, Myelomonocytic, Juvenile / pathology
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Leukemia, Myelomonocytic, Juvenile / therapy
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Neoplasm Staging
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Phosphorylation
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STAT5 Transcription Factor / metabolism*
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Signal Transduction* / genetics
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Treatment Outcome
Substances
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Biomarkers, Tumor
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STAT5 Transcription Factor
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Granulocyte-Macrophage Colony-Stimulating Factor
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JAK2 protein, human
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Janus Kinase 2