Modeling the effects of resection, radiation and chemotherapy in glioblastoma

J Neurooncol. 2009 Feb;91(3):287-93. doi: 10.1007/s11060-008-9710-6. Epub 2008 Oct 4.

Abstract

The standard treatment for newly diagnosed glioblastoma multiforme is surgical resection followed by radiotherapy and chemotherapy. Most studies on these treatments are retrospective clinical data analysis. To integrate these studies, a mathematical model is developed. The model predicts the survival time of patients who undergo resection, radiation, and chemotherapy with different protocols.

MeSH terms

  • Antineoplastic Agents / therapeutic use*
  • Brain Neoplasms / therapy*
  • Combined Modality Therapy / methods
  • Glioblastoma / therapy*
  • Humans
  • Models, Biological*
  • Neurosurgical Procedures / methods*
  • Radiotherapy*
  • Time Factors

Substances

  • Antineoplastic Agents