Lack of NMDA-AMPA interaction in antidepressant-like effect of CGP 37849, an antagonist of NMDA receptor, in the forced swim test

Małgorzata Dybała; Agata Siwek; Ewa Poleszak; Andrzej Pilc; Gabriel Nowak

doi:10.1007/s00702-008-0128-2

Lack of NMDA-AMPA interaction in antidepressant-like effect of CGP 37849, an antagonist of NMDA receptor, in the forced swim test

J Neural Transm (Vienna). 2008 Nov;115(11):1519-20. doi: 10.1007/s00702-008-0128-2. Epub 2008 Oct 7.

Authors

Małgorzata Dybała¹, Agata Siwek, Ewa Poleszak, Andrzej Pilc, Gabriel Nowak

Affiliation

¹ Laboratory of Pharmacobiology, Department of Cytobiology and Histochemistry, Collegium Medicum, Jagiellonian University, Medyczna 9, 30-688, Kraków, Poland.

PMID: 18839056
DOI: 10.1007/s00702-008-0128-2

Abstract

The NMDA receptor antagonist, CGP 37849-induced reduction in immobility time in the forced swim test in mice was not antagonized by pre-treatment with the AMPA receptor antagonist NBQX. This is the first demonstration of the antidepressant effect of the NMDA antagonist not being dependent on the AMPA transmission.

MeSH terms

2-Amino-5-phosphonovalerate / analogs & derivatives*
2-Amino-5-phosphonovalerate / pharmacology
Animals
Antidepressive Agents / pharmacology*
Depressive Disorder / psychology*
Excitatory Amino Acid Antagonists / pharmacology*
Mice
Motor Activity / drug effects
N-Methylaspartate / metabolism
N-Methylaspartate / physiology*
Quinoxalines / pharmacology
Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors*
Swimming / psychology*
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid / metabolism*

Substances

Antidepressive Agents
Excitatory Amino Acid Antagonists
Quinoxalines
Receptors, N-Methyl-D-Aspartate
2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline
2-amino-4-methyl-5-phosphono-3-pentenoic acid
N-Methylaspartate
2-Amino-5-phosphonovalerate
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid