Abstract
A small family of S-DABO cytosine analogs (S-DABOCs) has been synthesized and biologically evaluated as HIV-1 inhibitor both on wild type (wt) and drug-resistant mutants leading to the identification of an interesting compound (5d). Molecular modeling studies have been finally performed in order to rationalize the results.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-HIV Agents / chemical synthesis*
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Anti-HIV Agents / chemistry
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Anti-HIV Agents / pharmacology*
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Cytosine / analogs & derivatives*
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Cytosine / chemical synthesis
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Cytosine / chemistry
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Cytosine / pharmacology
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HIV-1 / drug effects
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Microbial Sensitivity Tests
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Models, Molecular