Abstract
We studied the effects of nateglinide on serum adiponectin in 26 patients with type 2 diabetes mellitus. The changes in serum insulin at 30min significantly correlated with those in serum high-molecular weight adiponectin. Nateglinide may ameliorate hypoadiponectinemia as well as postprandial hyperglycemia in patients with type 2 diabetes mellitus.
MeSH terms
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Adiponectin / blood
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Adiponectin / deficiency*
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Aged
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Cyclohexanes / administration & dosage
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Cyclohexanes / pharmacology*
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Diabetes Mellitus, Type 2 / complications
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Diabetes Mellitus, Type 2 / drug therapy*
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Female
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Humans
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Hyperglycemia / drug therapy
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Hypoglycemic Agents / administration & dosage
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Hypoglycemic Agents / pharmacology
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Insulin / blood
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Male
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Middle Aged
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Molecular Weight
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Nateglinide
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Phenylalanine / administration & dosage
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Phenylalanine / analogs & derivatives*
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Phenylalanine / pharmacology
Substances
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Adiponectin
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Cyclohexanes
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Hypoglycemic Agents
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Insulin
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Nateglinide
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Phenylalanine