We use angle resolved photoemission spectroscopy to study the momentum dependence of the superconducting gap in NdFeAsO0.9F0.1 single crystals. We find that the Gamma hole pocket is fully gapped below the superconducting transition temperature. The value of the superconducting gap is 15+/-1.5 meV and its anisotropy around the hole pocket is smaller than 20% of this value-consistent with an isotropic or anisotropic s-wave symmetry of the order parameter. This is a significant departure from the situation in the cuprates, pointing to the possibility that the superconductivity in the iron arsenic based system arises from a different mechanism.