Abstract
This study describes an in vivo model for evaluating the sterilizing activity of compounds against persisting Mycobacterium tuberculosis. The initial treatment with isoniazid and rifampin in granulocyte-macrophage colony-stimulating factor gene-disrupted mice reduced the number of bacteria more than 99% within 3 weeks. A subsequent treatment with individual drugs was performed to assess their activity on the 1% of remaining bacilli and disease relapse.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Animals
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Antitubercular Agents / therapeutic use*
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Bacillus / drug effects
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Disease Models, Animal
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Granulocyte-Macrophage Colony-Stimulating Factor / genetics*
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Lung / drug effects
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Lung / microbiology
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Mice
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Mice, Mutant Strains
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Mycobacterium tuberculosis / drug effects*
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Spleen / drug effects
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Spleen / microbiology
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Tuberculosis / drug therapy*
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Tuberculosis / genetics*
Substances
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Antitubercular Agents
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Granulocyte-Macrophage Colony-Stimulating Factor