Abstract
Pestalazines A (1) and B (2), two new diketopiperazine heterodimers, and pestalamides A-C (3-5), three new amides, have been isolated from cultures of the plant pathogenic fungus Pestalotiopsis theae. The structures of these compounds were elucidated mainly by NMR spectroscopy. The absolute configurations of 1 and 2 were determined using Marfey's method on their acid hydrolysates and by comparison of their CD spectra with that of a model compound. Compounds 1, 3, and 6 displayed inhibitory effects on HIV-1 replication in C8166 cells. Compound 3 also showed potent antifungal activity against Aspergillus fumigatus.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-HIV Agents / chemistry
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Anti-HIV Agents / isolation & purification*
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Anti-HIV Agents / pharmacology*
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Ascomycota / chemistry*
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Aspergillus fumigatus / drug effects
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Camellia sinensis / microbiology
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Diketopiperazines / chemistry
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Diketopiperazines / isolation & purification*
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Diketopiperazines / pharmacology*
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Humans
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Indole Alkaloids / chemistry
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Indole Alkaloids / isolation & purification*
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Indole Alkaloids / pharmacology*
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
Substances
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Anti-HIV Agents
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Diketopiperazines
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Indole Alkaloids
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pestalazine A
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pestalazine B