Computed tomography (CT) is the study of choice for the detection and staging of Hodgkin and non-Hodgkin lymphoma. CT enables accurate measurement of both tumor extent and volume and provides information that can be used to plan an appropriate therapeutic regimen as well as follow patient response to therapy. This article presents a systematic review of the common and uncommon appearances of lymphoma in the chest and abdomen. Potential pitfalls and limitations of CT in staging and follow-up are also addressed.