Cutaneous T-cell lymphoma (CTCL) represents a spectrum of the non-Hodgkin's lymphomas, including mycosis fungoides (MFs) and Sezary syndrome. Although an uncommon malignancy, the number of new cases per year in the United States is increasing at a constant rate. This paper provides an overview of CTCL, including pathophysiology, information on the various treatment modalities, and practical clinical approaches needed by oncology nurses to assist individuals experiencing treatment-related toxicities. Psychosocial issues, an aspect of disease in which oncology nurses can provide support and understanding, also are addressed.