Abstract
Innate immune responses mediated by Toll-like receptors (TLRs), a class of pattern-recognition receptors, play a critical role in the defense against microbial pathogens. However, excessive TLR-mediated responses result in sepsis, autoimmunity, and chronic inflammation. To prevent deleterious activation of TLRs, cells have evolved multiple mechanisms that inhibit innate immune reactions. Stimulation of TLRs induces the expression of the gene encoding the mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1), a nuclear-localized dual-specificity phosphatase that preferentially dephosphorylates p38 MAPK and c-Jun N-terminal kinase (JNK), resulting in the attenuation of TLR-triggered production of proinflammatory cytokines. MKP-1 is posttranslationally modified by multiple mechanisms, including phosphorylation. A study now demonstrates that MKP-1 is also acetylated on a key lysine residue following stimulation of TLRs. Acetylation of MKP-1 promotes the interaction of MKP-1 with its substrate p38 MAPK, which results in dephosphorylation of p38 MAPK and the inhibition of innate immunity.
MeSH terms
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Acetylation / drug effects
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Animals
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Autoimmunity / drug effects
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Chromatin Assembly and Disassembly / drug effects
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Chromatin Assembly and Disassembly / immunology*
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Cytokines / biosynthesis
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Cytokines / immunology*
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Dual Specificity Phosphatase 1 / immunology*
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Dual Specificity Phosphatase 1 / metabolism
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Enzyme Inhibitors / immunology
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Enzyme Inhibitors / pharmacology
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Histone Deacetylase Inhibitors
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Histone Deacetylases / immunology
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Histone Deacetylases / metabolism
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Humans
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Immunity, Innate* / drug effects
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Inflammation / drug therapy
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Inflammation / enzymology
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Inflammation / immunology
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Inflammation Mediators / immunology*
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Inflammation Mediators / metabolism
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JNK Mitogen-Activated Protein Kinases / immunology
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JNK Mitogen-Activated Protein Kinases / metabolism
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Phosphorylation / drug effects
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Phosphorylation / immunology
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Sepsis / drug therapy
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Sepsis / enzymology
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Sepsis / immunology
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Toll-Like Receptors / immunology
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Toll-Like Receptors / metabolism
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p38 Mitogen-Activated Protein Kinases / immunology
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p38 Mitogen-Activated Protein Kinases / metabolism
Substances
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Cytokines
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Enzyme Inhibitors
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Histone Deacetylase Inhibitors
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Inflammation Mediators
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Toll-Like Receptors
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JNK Mitogen-Activated Protein Kinases
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p38 Mitogen-Activated Protein Kinases
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DUSP1 protein, human
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Dual Specificity Phosphatase 1
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Histone Deacetylases