Targeting Val 216 in class A beta-lactamases with tricyclic 6-methylidene penems

ChemMedChem. 2008 Nov;3(11):1658-61. doi: 10.1002/cmdc.200800167.
No abstract available

MeSH terms

  • Antidepressive Agents, Tricyclic / chemical synthesis*
  • Antidepressive Agents, Tricyclic / chemistry
  • Catalytic Domain
  • Chemistry, Pharmaceutical / methods
  • Drug Design
  • Hydrogen / chemistry
  • Hydrolysis
  • Inhibitory Concentration 50
  • Models, Chemical
  • Models, Molecular
  • Molecular Conformation
  • Software
  • Thiazepines / chemistry
  • Valine / chemistry*
  • beta-Lactamases / chemistry*
  • beta-Lactamases / metabolism

Substances

  • Antidepressive Agents, Tricyclic
  • Thiazepines
  • Hydrogen
  • beta-Lactamases
  • Valine