Abstract
MCS-18, a natural product isolated from Helleborus purpurascens has been shown to have several beneficial effects in inflammatory and autoimmune disorders. However, very little is known regarding the immuno-modulatory capacity of MCS-18 in respect to murine bone marrow-derived dendritic cells (BM-DC) and B-cells. Thus, in the present study we examined the effect of MCS-18 on murine BM-DC and B-cells. Interestingly MCS-18 inhibited the expression of important DC-specific molecules and lead to an impaired T-cell stimulation capacity. In addition, MCS-18 also reduced B-cell proliferation and immunoglobulin production.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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B-Lymphocytes / drug effects*
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B-Lymphocytes / immunology
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B-Lymphocytes / metabolism
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Biological Products / isolation & purification
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Biological Products / pharmacology*
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Bone Marrow Cells / drug effects*
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Bone Marrow Cells / immunology
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Cell Proliferation / drug effects
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Dendritic Cells / drug effects*
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Dendritic Cells / immunology
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Dendritic Cells / metabolism
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Helleborus / chemistry
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Immunoglobulin G / biosynthesis
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Immunoglobulin G / drug effects
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Immunoglobulin M / biosynthesis
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Immunoglobulin M / drug effects
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Immunologic Factors / isolation & purification
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Immunologic Factors / pharmacology*
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Mice
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Mice, Inbred BALB C
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Mice, Inbred C57BL
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T-Lymphocytes / drug effects
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T-Lymphocytes / immunology*
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T-Lymphocytes / metabolism
Substances
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Biological Products
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Immunoglobulin G
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Immunoglobulin M
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Immunologic Factors
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MCS-18